| 產(chǎn)品編號 | bs-8019R-BF594 |
| 英文名稱 | Rabbit Anti-ICMT/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的異戊烯半胱氨酸羧基甲基轉(zhuǎn)移酶抗體 |
| 別 名 | CMT; HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC39955; MGC95322; MST098; MSTP098; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-methyltransferase; RP23-421E12.4; STE14; fcmt. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMT/Icmt |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. Similarity: Belongs to the isoprenylcysteine O-methyltransferase family. Database links: Entrez Gene: 23463 Human Entrez Gene: 57295 Mouse Omim: 605851 Human SwissProt: O60725 Human SwissProt: Q9EQK7 Mouse Unigene: 515688 Human Unigene: 277464 Mouse Unigene: 48709 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Icmt酶是異戊烯途徑中的一種關(guān)鍵酶，它能將甲基加到Ras上。這種甲基標(biāo)簽?zāi)苁筊as到達細(xì)胞中的最終目的地，Icmt酶能發(fā)送不控制生長的信號，因此，Icmt蛋白在保持細(xì)胞中的致癌基因Ras的開啟狀態(tài)中起到重要作用。（Ras是細(xì)胞的一種正常的遺傳成分，但是這種基因的突變能夠致使它促進細(xì)胞的失控生長。而且，在一半的結(jié)腸癌和90％的胰腺癌中發(fā)生了Ras基因突變）。 |
