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Rabbit Anti-Thromboxane synthase/Cy5 Conjugated antibody (bs-4019R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@www.ssxsbs.com
訂購QQ:  400-901-9800
技術支持:techsupport@www.ssxsbs.com
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4019R-Cy5
英文名稱 Rabbit Anti-Thromboxane synthase/Cy5 Conjugated antibody
中文名稱 Cy5標記的血栓素合成酶抗體
別    名 CYP5; CYP5A1; Cytochrome P450 5A1; TBXAS1; THAS; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; TS; TXA synthase; TXAS; TXS.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  轉錄調節因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thromboxane synthase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Thromboxane Synthase is a useful marker for the detection of native thromboxane synthase in smears, isolated cells, human tissue sections, and for affinity purification of the enzyme. In combination with the markers 27E10, RM 3/1 and 25F9, anti Thromboxane Synthase enables a more precise characterization of inflammatory processes in injured tissues, or in vitro cell-cell interaction studies. Distribution of thromboxane synthase in human tissues: Thromboxane synthase is predominantly produced by macrophages or antigen presenting cells of the myelo-monocytic lineage as shown below. Endothelial cells of placenta and epithelial cells in tonsils and bronchi also express this enzyme.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

DISEASE:
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.

Similarity:
Belongs to the cytochrome P450 family.

Database links:

Entrez Gene: 6916 Human

Entrez Gene: 21391 Mouse

Entrez Gene: 397112 Pig

Entrez Gene: 24886 Rat

Omim: 274180 Human

SwissProt: P24557 Human

SwissProt: P36423 Mouse

SwissProt: P47787 Pig

SwissProt: P49430 Rat

Unigene: 520757 Human

Unigene: 4054 Mouse

Unigene: 16283 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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