| 產(chǎn)品編號(hào) | bsm-63160R |
| 英文名稱 | Insulin receptor Recombinant Rabbit mAb |
| 中文名稱 | 胰島素受體重組兔單抗 |
| 別 名 | CD220; HHF5; human insulin receptor; Insr; Insulin receptor subunit beta; IR 1; IR. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 5B3 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 156 kDa |
| 檢測(cè)分子量 | 95 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Insulin receptor: 910-976 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. SWISS: P06213 Gene ID: 3643 胰島素受體是一個(gè)四聚體，由兩個(gè)α亞基和兩個(gè)β亞基通過(guò)二硫鍵連接。兩個(gè)α亞基位于細(xì)胞質(zhì)膜的外側(cè)，其上有胰島素的結(jié)合位點(diǎn)；兩個(gè)β亞基是跨膜蛋白，起信號(hào)轉(zhuǎn)導(dǎo)作用。無(wú)胰島素結(jié) 合時(shí)，受體的酪氨酸蛋白激酶沒(méi)有活性。當(dāng)胰島素與受體的α亞基結(jié)合并改變了β亞基的構(gòu)型后，酪氨酸蛋白激酶才被激活，激活后可催化兩個(gè)反應(yīng)： ①使四聚體復(fù)合物中β亞基特異位點(diǎn)的酪氨酸殘基磷酸化,這種過(guò)程稱為自我磷酸化（autophosphorylation)； ②將胰島素受體底物(insulin receptor substrate，IRSs)上具 |
