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GS 441524 (D51745)  
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2mg/480.00元
10mg/1480.00元
大包裝/詢價
產(chǎn)品編號 D51745
英文名稱 GS 441524
中文名稱
別    名   FIPV抑制劑
CAS 1191237-69-0
理論分子量 291.26 kDa
檢測分子量
性    狀 Lyophilized
保存條件 Store in dry, dark place for one year.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 GS 441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS 441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS 441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS 441524 was non-toxic in feline cells at concentrations as high as 100uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS 441524 is an active metabolite of Remdesivir.

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