| 產(chǎn)品編號(hào) | bsm-43017M |
| 英文名稱(chēng) | MMP3 Mouse mAb |
| 中文名稱(chēng) | 基質(zhì)金屬蛋白酶3單克隆抗體 |
| 別 名 | MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3(MMP-3); MMP-3; MMP 3; Transin-1; |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號(hào) | 4F4 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 52 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human MMP-3 protein: 18-477/477 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: P08254 Gene ID: 4314 Database links: Entrez Gene: 4314 Human Entrez Gene: 17392 Mouse Omim: 185250 Human SwissProt: P08254 Human SwissProt: P28862 Mouse Unigene: 375129 Human 合成與降解（Synthesis and Degradation） 基質(zhì)金屬蛋白酶(matrix metalloproteinases, MMPs)是一族依賴(lài)鋅離子而降解各種細(xì)胞外基質(zhì)的蛋白酶，亦稱(chēng)IV型膠原酶或稱(chēng)明膠酶A，其主要功能為降解IV型膠原，因而它在腫瘤細(xì)胞突破基底膜屏障和浸潤(rùn)轉(zhuǎn)移中起重要作用。 MMP3目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測(cè)與腫瘤轉(zhuǎn)移浸潤(rùn)的研究。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Recombinant human MMP-3 protein
Primary: Anti-MMP3 (bsm-43017M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 60 kDa
|
