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BACE2 Rabbit pAb (bs-11680R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-11680R
英文名稱 BACE2 Rabbit pAb
中文名稱 β淀粉樣前體蛋白裂解酶2抗體
別    名 ALP 56; ALP-56; ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; beta Secretase 2; beta Secretase 2; beta Site Amyloid beta A4 Precursor Protein Cleaving Enzyme 2; beta Site Amyloid beta A4 Precursor Protein Cleaving Enzyme 2; beta-secretase 2; beta-site amyloid precursor protein cleaving enzyme 2; beta-site APP cleaving enzyme 2; beta-site APP cleaving enzyme 2; Down region aspartic protease; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase.  
研究領域 細胞生物  神經生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 細胞外基質 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BACE2: 101-200/518 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Subunit:
Monomer. Interacts ith RTN3 and RTN4.

Subcellular Location:
Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.

Tissue Specificity:
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.

Post-translational modifications:
Undergoes autoproteolytic cleavage.
Glycosylated.

Similarity:
Belongs to the peptidase A1 family.

SWISS:
Q9Y5Z0

Gene ID:
25825

Database links:

Entrez Gene: 25825 Human

Entrez Gene: 56175 Mouse

Entrez Gene: 288227 Rat

Omim: 605668 Human

SwissProt: Q9Y5Z0 Human

SwissProt: Q9JL18 Mouse

SwissProt: Q6IE75 Rat

Unigene: 529408 Human

Unigene: 97885 Mouse

Unigene: 38581 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BACE2) Polyclonal Antibody, Unconjugated (bs-11680R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BACE2) Polyclonal Antibody, Unconjugated (bs-11680R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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