| 產(chǎn)品編號 | bs-0499P |
| 英文名稱 | Humanin (Gly-HN) Peptide |
| 中文名稱 | 神經(jīng)保護(hù)肽 |
| 別 名 | HN; HNG; 強(qiáng)效的humanin類似物HNG; |
| 克 隆 號 | |
| 理論分子量 | 2.657 kDa |
| 檢測分子量 | |
| 性 狀 | Lyophilized |
| 物 種 | human |
| 序 列 | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| 純化方法 | 1 |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles. note="S->G(Site 14): Potentiates neuroprotective activity." Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala MW:2657 Humanin (HN) 是一種新近發(fā)現(xiàn)的神經(jīng)保護(hù)性多肽，能夠特異且有效地阻斷由家族性阿爾茨海默病(FAD)基因和β淀粉樣肽(Aβ)引起的細(xì)胞死亡。其作用機(jī)制可能是HN通過特異地阻斷某些細(xì)胞死亡的信號通路來起到對細(xì)胞的保護(hù)作用。這些研究結(jié)果為抗阿爾茨海默病(AD)藥物的研發(fā)提供了非常有價值的信息。 |
