| 產品編號 | bs-2374R |
| 英文名稱 | TAP2 Rabbit pAb |
| 中文名稱 | ATP結合轉運因子2抗體 |
| 別 名 | ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; RING 11; TAP 2; Transporter 2 ATP binding cassette sub family B. |
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Specific References (1) | bs-2374R has been referenced in 1 publications.
[IF=17.694] Lei, Xin. et al. CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment. NAT COMMUN. 2023 Jan;14(1):1-14 FCM ; Human.
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| 研究領域 | 腫瘤 細胞生物 免疫學 信號轉導 轉錄調節因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產品應用 | Flow-Cyt=1μg/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 75 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TAP2: 451-550/686 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. SWISS: Q03519 Gene ID: 6891 Database links: Entrez Gene: 6891?/span>Human Omim: 170261?/span>Human SwissProt: Q03519?/span>Human Unigene: 502?/span>Human |
| 產品圖片 |
Fixed and permeabilized EL-4 cells were labeled with Rabbit Anti- TAP2/ABCB3 Polyclonal Antibody, Unconjugated (bs-2374R) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG FITC conjugated Secondary Antibody at 1:200 dilution.
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| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
